A coordinated interaction between economy and eco-environment has become a vital topic of social economy. In order to reach high\|quality development of Yangtze river economic zone, this paper uses spatial metering and panel threshold model to study the relation of industrial clustering with water pollution in 11 provinces (cities) in Yangtze river economic zone from 2007 to 2018 Such water environmental pollution has significant spatial autocorrelation. Impacts of industrial clustering on water environmental pollution in Yangtze river economic zone show a U-shaped curve, indicating existence of threshold in industrial pollution over water environmental pollution. Scale effect and structural effect of industrial clustering in Yangtze river economic zone have a striking double threshold effect on water environmental pollution with their exterior characteristics varying with industrial clustering levels, so does technical overflow effect, which will show a strong-to-weak trend on water environmental pollution as industrial clustering level grows.